| Title | HIV-1 remission and possible cure in a woman after haplo-cord blood transplant. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Hsu J, Van Besien K, Glesby MJ, Pahwa S, Coletti A, Warshaw MG, Petz L, Moore TB, Chen YHui, Pallikkuth S, Dhummakupt A, Cortado R, Golner A, Bone F, Baldo M, Riches M, Mellors JW, Tobin NH, Browning R, Persaud D, Bryson Y |
| Corporate Authors | International Maternal Pediatric Adolescent AIDS Clinical Trials Network(IMPAACT) P1107 Team |
| Journal | Cell |
| Volume | 186 |
| Issue | 6 |
| Pagination | 1115-1126.e8 |
| Date Published | 2023 Mar 16 |
| ISSN | 1097-4172 |
| Abstract | Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32) allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant (cord blood cells combined with haploidentical stem cells from an adult) to treat acute myeloid leukemia (AML). Peripheral blood chimerism was 100% CCR5Δ32/Δ32 cord blood by week 14 post-transplant and persisted through 4.8 years of follow-up. Immune reconstitution was associated with (1) loss of detectable replication-competent HIV-1 reservoirs, (2) loss of HIV-1-specific immune responses, (3) in vitro resistance to X4 and R5 laboratory variants, including pre-transplant autologous latent reservoir isolates, and (4) 18 months of HIV-1 control with aviremia, off antiretroviral therapy, starting at 37 months post-transplant. CCR5Δ32/Δ32 haplo-cord transplant achieved remission and a possible HIV-1 cure for a person of diverse ancestry, living with HIV-1, who required a stem cell transplant for acute leukemia. |
| DOI | 10.1016/j.cell.2023.02.030 |
| Alternate Journal | Cell |
| PubMed ID | 36931242 |