Title | Plasma metabolomic analysis indicates flavonoids and sorbic acid are associated with incident diabetes: A nested case-control study among Women's Interagency HIV Study participants. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Yu EA, Alemán JO, Hoover DR, Shi Q, Verano M, Anastos K, Tien PC, Sharma A, Kardashian A, Cohen MH, Golub ET, Michel KG, Gustafson DR, Glesby MJ |
Journal | PLoS One |
Volume | 17 |
Issue | 7 |
Pagination | e0271207 |
Date Published | 2022 |
ISSN | 1932-6203 |
Keywords | Case-Control Studies, Diabetes Mellitus, Type 2, Female, Flavonoids, HIV Infections, Humans, Risk Factors, Sorbic Acid |
Abstract | INTRODUCTION: Lifestyle improvements are key modifiable risk factors for Type 2 diabetes mellitus (DM) however specific influences of biologically active dietary metabolites remain unclear. Our objective was to compare non-targeted plasma metabolomic profiles of women with versus without confirmed incident DM. We focused on three lipid classes (fatty acyls, prenol lipids, polyketides). MATERIALS AND METHODS: Fifty DM cases and 100 individually matched control participants (80% with human immunodeficiency virus [HIV]) were enrolled in a case-control study nested within the Women's Interagency HIV Study. Stored blood samples (1-2 years prior to DM diagnosis among cases; at the corresponding timepoint among matched controls) were assayed in triplicate for metabolomics. Time-of-flight liquid chromatography mass spectrometry with dual electrospray ionization modes was utilized. We considered 743 metabolomic features in a two-stage feature selection approach with conditional logistic regression models that accounted for matching strata. RESULTS: Seven features differed by DM case status (all false discovery rate-adjusted q<0.05). Three flavonoids (two flavanones, one isoflavone) were respectively associated with lower odds of DM (all q<0.05), and sorbic acid was associated with greater odds of DM (all q<0.05). CONCLUSION: Flavonoids were associated with lower odds of incident DM while sorbic acid was associated with greater odds of incident DM. |
DOI | 10.1371/journal.pone.0271207 |
Alternate Journal | PLoS One |
PubMed ID | 35802662 |
PubMed Central ID | PMC9269977 |
Grant List | U01 AI031834 / AI / NIAID NIH HHS / United States U01 AI035004 / AI / NIAID NIH HHS / United States K08 DK117064 / DK / NIDDK NIH HHS / United States U01 AI034994 / AI / NIAID NIH HHS / United States U01 AI034993 / AI / NIAID NIH HHS / United States UL1 RR024131 / RR / NCRR NIH HHS / United States U01 AI034989 / AI / NIAID NIH HHS / United States U01 HD032632 / HD / NICHD NIH HHS / United States U01 AI042590 / AI / NIAID NIH HHS / United States |